It’s like a hangover

My fellow inebriates,

The day after the COVID-19 vaccine is kind of like a hangover. You feel kind of tired, a bit icky and sort of prickly. Your throat feels a tad rough—and did someone punch you in the arm?

You’ve been through worse (especially if you’re in the habit of following my advice).

You can do it! Go get your shot.

Polo Gin—the AstraZeneca of gins

My fellow inebriates,

Last week’s directions from the government were: “The best vaccine is the one you’re offered.” This get-what-you-get-and-don’t-get-upset advice was being applied to AstraZeneca, the budget monkey adenovirus vaccine with an infinitesimally small (but nonetheless actual) blood-clot risk.

Photo by Artem Podrez on Pexels.com

Then the National Advisory Committee on Immunization (NACI) came out with an unequivocal statement that mRNA vaccines (Pfizer and Moderna) are better than AZ. Not only do they have a higher efficacy; they do not carry the same risk (so far) of vaccine-induced thrombotic thrombocytopenia.

Today Dr. Caroline Quach (favourite doctor name ever) of NACI is trying to assuage AZ recipients’ “vaccine remorse”—telling them they did the right thing to protect themselves, especially if they were at moderate or high risk for catching COVID-19.*

This could be construed in a highly problematic way—frontline workers and at-risk populations being hustled into the arms of AZ while those at low risk sequester themselves comfortably in their remote offices and await Pfizer and Moderna.

To hint further at the inequity here, a shot of AstraZeneca costs about 4 bucks. Pfizer and Moderna cost, respectively, $19.50 and $25-37 per dose.

VaccineTypeCost per doseEfficacy
AstraZenecaAdenovirus-based$3-470% overall. Effective against UK and Brazilian variants but not the South African variant.
Johnson & JohnsonAdenovirus-based$1066-72%, depending on the study. 100% effective at preventing hospitalization and death. More effective against UK variant than South African and Brazilian strains.
ModernamRNA$25-3795%. 100% at preventing hospitalization and death. “Quite effective” against all variants. (OMG, what does “quite” mean?)
Pfizer-BioNTechmRNA$19.5095%. 100% at preventing hospitalization and death. 95%. 100% at preventing hospitalization and death. “Quite effective” against all variants. (Again, “quite”?)
Sputnik VAdenovirus-based$1091.4% No data on variants.
Sinovac BiotechInactivated
SARS-CoV-2 virus
$29.7550.38-91.25%, depending on the study. No data on variants.
NovavaxProtein-based$1689.3% Works against South African and UK variants.
CanSinoViral vector (using
SARS-CoV-2 antigen)
?65.7% at preventing symptomatic cases. 90.98% at preventing severe disease. No data on variants.
BharatInactivated SARS-CoV-2 virus$278% against mild to moderate infection. 100% against severe infection. Works against UK variant.

It reminds me of when the only gin in the house was Polo Club, a cheap dry gin from Wisconsin with a knifey flavour profile and overaggressive zest. No matter what you mixed with Polo Club, its hostile character would slice through, killing your chill and urging you to pound your drink so you could thoroughly rinse the glass and put something else in it.

At the time, all of us at LBHQ agreed that Polo Club was unacceptable. My parents said they would hold off on making G&Ts until it occurred to them to buy a decent gin. (This was an open-ended prospect, as their consumption of gin is highly weather dependent and usually isn’t triggered unless they have a party.)

I, however, am an alcoholic, so I was not willing to wait for Bombay or Broker’s. I took the gin that was offered to me. As I sipped, I could feel it shredding my fur from the inside out. I told myself it was okay—because it was timely. And it was somewhat satisfying. Once I’d doctored it up with lots of lime, it scored about 70%.

“The best gin is the one in the liquor cabinet right now.”

You may think it’s in bad taste to compare my gin-seeking recourse to Polo Club with the urging of millions of people toward a lesser vaccine that they accepted because they were at risk and it couldn’t come fast enough.

Of course it’s a tacky comparison.

But it’s a tacky reality too—in the light of NACI’s statement about mRNA vaccines being better, who wouldn’t prefer Pfizer or Moderna? And why shouldn’t they?

My dad was lucky to be offered the Pfizer vaccine at his workplace. My mum was stubborn and held out for it. We recognize what a luxury this was. She’s not frontline and she’s not in a vulnerable category, so she felt comfortable waiting.

But some people couldn’t wait. Time will tell whether it was fair that they stepped forward first for AstraZeneca.

And some bears can’t wait either. That’s why I took the gin that was offered to me. I would have put out my paw out for the AZ too.**

*Public health, get your shit together. We get it—the data are coming in on a daily and even hourly basis. But don’t make Dr. Quach walk back her statement about mRNA vaccines being better. She’s a scientist. Acknowledge what she says and go forward with honesty and transparency.

**Except there’s no point, because bears are a veritable cesspool of serious germs that would kick COVID’s spike proteins to kingdom come.

Can you drink after the COVID-19 vaccine?

My fellow inebriates,

My dad has had his first dose of the vaccine, and my mum is on the list. As you know, bears need no vaccine because we are already petri dishes of jockeying germs, and COVID wouldn’t make a difference to us.

My dad got the shot shortly after having actual COVID, which kicked his ass for a good three weeks. Just as he was starting to recover, BAM! Pfizer kicked his ass with three bonus days of fever and sweats. All good now, though.

Perhaps needless to say, my dad wasn’t much of a party animal as we headed into spring. Where once I could rely on him to pour (and share) a beer or whiskey in the evening, COVID-infected Dad was no fun at all.

(To recap why I depend on my parents to open the bar, I have no thumbs.)

So now my mum’s about to get her jab, and she’s talking about abstaining from alcohol to maximize her immune response.

I immediately went to Google to find some evidence against this sort of extremist action.

The idea that alcohol could mess with immunity first surfaced in Russia, where a health official recommended abstaining two weeks before the vaccine and 42 days afterward. Russians were incensed by this of course.

Photo by Karolina Grabowska on Pexels.com

There is no evidence for this recommendation. No COVID/alcohol studies have been conducted. All we have to go on is the evidence from past studies on animals to see whether alcohol affected their immune responses after vaccination. Where do I sign up for one of those animal studies? (It helps to be a rat or a monkey.)

What evidence is there?

Subjects with alcohol use disorder have increased susceptibility to viral and bacterial infections. Moderate alcohol use is associated with an enhanced immune response.

Monkeys who were given all-access drinking privileges for seven months and whose blood/alcohol levels regularly exceeded 80 mg/ml had a lowered immune response. But monkeys who drank moderately had higher levels of antiviral cytokines.

So, Mum, moderate is the way to go. And moderate is okay. To be honest, I don’t need to see my you or Dad bust out these days—it would be embarrassing for everybody. Just pour yourself 1.5 oz. of something nice, and be ready to share it with this would-be experimental bear.